Recombinant Mouse CXCL12 Protein (11.6 kDa)

IBI’s recombinant mouse CXCL12 protein is a high-quality research tool designed for studies of cell migration, survival, and apoptosis. Produced using a Pichia pastoris (yeast) system, this protein benefits from superior folding and post-translational modifications, ensuring enhanced bioactivity and structural fidelity compared to E. coli-derived alternatives. Free from endotoxins, HIS-TAGS, and carriers, it closely resembles its native form, with a predicted molecular weight of 11.6 kDa.

CXCL12, also known as stromal cell-derived factor 1, plays a critical role in immune cell chemoattraction and signaling. Unlike most chemokines, CXCL12 exclusively binds to the CXCR4 receptor, mediating processes such as cellular migration, survival, and apoptosis across various tissues. This protein-receptor pairing is essential for life, as deficiencies in CXCL12 or CXCR4 are lethal in early development. Beyond its physiological roles, CXCL12 and CXCR4 are implicated in diseases like cancer, HIV, and rheumatoid arthritis, making this protein a key focus of therapeutic and diagnostic research.

Shipped lyophilized at room temperature without carrier protein, IBI’s recombinant mouse CXCL12 protein can be easily reconstituted in sterile PBS with a carrier like BSA or cell assay media. Ideal for use in cell culture, as a CXCL12 ELISA standard, or as a Western Blot control, this protein ensures consistency and reliability for cutting-edge studies in immunology and disease pathways.