Recombinant Mouse IFN-Gamma Protein (15.5 kDa)

IBI’s recombinant mouse IFN-gamma protein is a superior tool for research focused on immune system regulation and antiviral defense. Expressed in a Pichia pastoris (yeast) system, this protein benefits from precise folding and post-translational modifications, resulting in exceptional bioactivity. Free from endotoxins, HIS-TAGS, and carriers, it closely mimics its native form, with a predicted molecular weight of 15.5 kDa. This purity and quality make it ideal for advanced research applications.

Role of IFN-Gamma in Immunity

Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine, essential for innate and adaptive immunity. It directly inhibits viral replication and exerts immunostimulatory effects, enhancing the immune system's ability to combat viral and intracellular bacterial infections, as well as tumor cells. Produced primarily by natural killer (NK) and natural killer T (NKT) cells during innate responses, and by CD4 and CD8 T cells during antigen-specific immunity, IFN-gamma plays a crucial role in immune modulation. Aberrant expression of IFN-gamma is linked to autoimmune and autoinflammatory diseases, highlighting its importance in maintaining immune balance.

Shipped lyophilized at room temperature without carrier protein, IBI’s recombinant mouse IFN-gamma protein is easily reconstituted in sterile PBS with a suitable carrier such as BSA or cell assay media. It is ideal for cell culture, ELISA standards, and Western Blot controls, providing consistent results for immunological research and beyond.